Those with no history of glucose intolerance, but with fasting blood glucose levels greater than 100 mg/dL at the time of enrollment were also excluded. Patients with a history of acute blood loss, hemolytic anemia, hemoglobinopathies, kidney disease, pregnancy, established diabetes, impaired fasting glucose, or impaired glucose tolerance were excluded. The patients were from both outpatient and inpatient departments of Lok Nayak Hospital, Delhi, India, and were enrolled after they provided written consent. Therefore, both because of this lack of corresponding evidence and since no such studies have been conducted on the Indian population, we were prompted to conduct the current study to investigate the effects of iron deficiency anemia on HbA1c levels in Indian patients.įifty patients (both men and women) aged between 12 and 50 yr with confirmed iron deficiency-type anemia were included in this study. The results of these studies are conflicting, and the exact mechanism underlying the effects of iron deficiency anemia on HbA1c levels is not yet known. Further studies showed that HbA1c levels were higher in patients with iron deficiency anemia and decreased significantly upon treatment with iron. investigated different methods to assay HbA1c levels and found no differences in HbA1c levels detected when using colorimetric assays, ion exchange chromatography, and affinity chromatography. These observations were strikingly different from those of previous studies. reported that there were no differences between the HbA1c levels of anemic patients and controls. revealed a relationship between iron deficiency anemia and HbA1c levels and attempted to explain the alteration in HbA1c levels in iron deficiency anemia on the basis of both modifications to the structure of hemoglobin and levels of HbA1c in old and new red blood cells. Iron deficiency anemia is the most common form of anemia in India. Vitamin B12, folate, and iron deficiency anemias have also been shown to affect HbA1c levels. They are also altered in hemolytic anemias, hemoglobinopathies, acute and chronic blood loss, pregnancy, and uremia. HbA1c levels are not affected by blood glucose levels alone. According to the American Diabetes Association Guidelines published in 2007, HbA1c levels should be maintained below 7% in all diabetic patients in order to prevent the development of microvascular complications. HbA1c is the predominant hemoglobin found in HbA1 fractions. Glycated hemoglobins, including HbA1c and other hemoglobins, constitute the HbA1 fraction of adult hemoglobin (HbA). Hemoglobin A1c (HbA1c) is a glycated hemoglobin that can be used as an indicator of a patient's glycemic status over the previous 3 months.
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